Publicações

Produção científica do grupo, organizada por ano. Nomes de membros do PKBio aparecem em negrito.

2026

  1. de Goes, P. R. N.; Taffarel, M. O.; Diniz, A.

    Application of physiologically‐based pharmacokinetic modelling to guide oral ketamine prescription in analgesic doses

    British Journal of Clinical Pharmacology Artigo DOI: 10.1002/bcp.70662

  2. Piai, J. M. B.; Lippa, V. N. M.; Caleffi-Marchesini, E. R.; Borghi Pangoni, F. B.; Felipe, M. S.; Kioshima, E. S.; Diniz, A.

    Integrating Experimental Physicochemical Data with PBPK Modeling to Guide the Translational Development of the Antifungal 1,3,4-Oxadiazole Derivative LMM6

    ACS Omega Artigo DOI: 10.1021/acsomega.6c00258

  3. Alencar, C. R. K. d.; Lachi-Silva, L.; Goes, P. R. N. d.; Sakamoto, G. F.; Diniz, A.; Ferrante, M.; Oliveira, A. R. d.; Trindade, P. H. E.; Puoli Filho, J. N. P.; Luna, S. P. L.; Taffarel, M. O.

    Pharmacokinetics of oral-transmucosal ketamine in horses

    Ciência Rural Artigo DOI: 10.1590/0103-8478cr20240251

  4. Lobato, A. H. P.; Piai, J. M.; Salamonczyk, D. d. L.; Abe, T. M. K.; Ferrari, G. L.; Diniz, A.; Matioli, G.; Pangoni, F. B. B.

    Water Solubility as a Key Parameter for Rational Dose Optimization of the Nutraceutical Rutin

    Brazilian Archives of Biology and Technology Artigo DOI: 10.1590/1678-4324-2026250815

2024

  1. Motta, V. P. P.; Silva, F. F. d.; Caruso, Í. P.; Goes, P. R. N. d.; Taffarel, M. O.; Diniz, A.; Seixas, F. A. V.

    Analysis of the ketamine binding to total plasma protein from domestic cats

    Brazilian Journal of Veterinary Research and Animal Science Artigo DOI: 10.11606/issn.1678-4456.bjvras.2024.219363

  2. Mantovani, P. C.; Borghi-Pangoni, F. B.; Nova, M. V.; Galan, V.; Santos, H. d.; Sato, F.; Bruschi, M. L.; Diniz, A.

    Could the Change of Excipient Content Improve the Stability of Gastroresistant Omeprazole Pellets?

    Brazilian Archives of Biology and Technology Artigo DOI: 10.1590/1678-4324-2024230850

  3. Borges, L. N.; Fernandes, E. A. F.; Oliveira, É. M. d.; Pereira, V. G.; Diniz, A.

    Experiences and initiatives on pharmacokinetic modeling and simulation data analysis: Perspectives from the Brazilian Health Regulatory Agency (ANVISA)

    Regulatory Toxicology and Pharmacology Artigo DOI: 10.1016/j.yrtph.2024.105728

2023

  1. Caleffi‐Marchesini, E. R.; Borghi‐Pangoni, F. B.; Macente, J.; Chiamulera‐Mantovani, P.; Mazucheli, J.; Cristofoletti, R.; Diniz, A.

    Exploring in vitro solubility of lamotrigine in physiologically mimetic conditions to prospect the in vivo dissolution in pediatric population

    Biopharmaceutics & Drug Disposition Artigo DOI: 10.1002/bdd.2353

  2. Pinheiro de Souza, F.; Sonego Zimmermann, E.; Tafet Carminato Silva, R.; Novaes Borges, L.; Villa Nova, M.; Miriam de Souza Lima, M.; Diniz, A.

    Model-Informed drug development of gastroretentive release systems for sildenafil citrate

    European Journal of Pharmaceutics and Biopharmaceutics Artigo DOI: 10.1016/j.ejpb.2022.12.001

  3. Macente, J.; Nauwelaerts, N.; Russo, F. M.; Deprest, J.; Allegaert, K.; Lammens, B.; Hernandes Bonan, R.; Turner, J. M.; Kumar, S.; Diniz, A.; Martins, F. S.; Annaert, P.

    PBPK-based dose finding for sildenafil in pregnant women for antenatal treatment of congenital diaphragmatic hernia

    Frontiers in Pharmacology Artigo DOI: 10.3389/fphar.2023.1068153

2022

  1. Do Crataegus pinnatifida capsules sold in Brazil undergo pharmaceutical quality control? Is there a quality control adopted in Brazil?

    Revista Brasileira de Plantas Medicinais Artigo

2021

  1. Soares, A. L. P.; Montanha, M. C.; Alcantara, C. d.; Silva, S. R.; Kuroda, C. M.; Yamada, S. S.; Nicacio, A. E.; Maldaner, L.; Visentainer, J. V.; Simões, C. F.; Locatelli, J. C.; …; Kimura, E.

    Pharmacokinetics of amoxicillin in obese and nonobese subjects

    British Journal of Clinical Pharmacology Artigo DOI: 10.1111/bcp.14739

2020

  1. Lachi-Silva, L.; Barth, A. B.; Santos, G. M. L.; Ahamadi, M.; Bruschi, M. L.; Kimura, E.; de Araújo, B. V.; Diniz, A.

    Population pharmacokinetics of orally administrated bromopride: Focus on the absorption process

    European Journal of Pharmaceutical Sciences Artigo DOI: 10.1016/j.ejps.2019.105081

2019

  1. Montanha, M. C.; Diniz, A.; Silva, N. M. E. N.; Kimura, E.; Paixão, P.

    Physiologically-Based Pharmacokinetic Model on the Oral Drug Absorption in Roux-en-Y Gastric Bypass Bariatric Patients: Amoxicillin Tablet and Suspension

    Molecular Pharmaceutics Artigo DOI: 10.1021/acs.molpharmaceut.9b00870

  2. Biesdorf, C.; Martins, F. S.; Sy, S. K.; Diniz, A.

    Physiologically‐based pharmacokinetics of ziprasidone in pregnant women

    British Journal of Clinical Pharmacology Artigo DOI: 10.1111/bcp.13872

  3. Montanha, M. C.; dos Santos Magon, T. F.; de Souza Alcantara, C.; Simões, C. F.; Silva, S. R. B.; Kuroda, C. M.; Yamada, S. S.; de Oliveira, L. E. S.; Nasser, D.; Junior, N. N.; Mazucheli, J.; …; Kimura, E.

    Reduced bioavailability of oral amoxicillin tablets compared to suspensions in Roux‐en‐Y gastric bypass bariatric subjects

    British Journal of Clinical Pharmacology Artigo DOI: 10.1111/bcp.14023

  4. Chavari, M.; Góes, P. R. N. d.; Lachi-Silva, L.; Barth, A. B.; Silva, A. O. F. d.; Longhini, R.; Mello, J. C. P. d.; Kimura, E.; Diniz, A.

    Simultaneous liquid chromatography- tandem mass spectrometry method to quantify epicatechin and procyanidin B2 in rat plasma after oral administration of Trichilia catigua (catuaba) extract and its application to a pharmacokinetic study

    Revista Brasileira de Farmacognosia Artigo DOI: 10.1016/j.bjp.2018.08.011

2018

  1. Oliveira, M. B.; da Silva, J. B.; Montanha, M. C.; Kimura, E.; Diniz, A.; Bruschi, M. L.

    Design and Characterization of Mucoadhesive Gelatin-Ethylcellulose Microparticles for the Delivery of Curcumin to the Bladder

    Current Drug Delivery Artigo DOI: 10.2174/1567201815666180503121043

  2. Cristofoletti, R.; Schmidt, S.; Diniz, A.

    Non-Procrustean Pathways for Complex Generic Drugs Development

    Therapeutic Delivery Artigo DOI: 10.4155/tde-2018-0047

2017

  1. Gouvea, D.; Buqui, G.; Lopes, J. L.; Diniz, A.; Lopes, N.

    An UPLC-MS/MS Method for Determination of Vicenin-2 and Lychnopholic Acid in Rat Plasma and its Application to a Pharmacokinetic Study

    Journal of the Brazilian Chemical Society Artigo DOI: 10.21577/0103-5053.20160249

  2. Borghi-Pangoni, F. B.; Junqueira, M. V.; de Souza Ferreira, S. B.; Silva, L. L.; Rabello, B. R.; de Castro, L. V.; Baesso, M. L.; Diniz, A.; Caetano, W.; Bruschi, M. L.

    Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy

    Photodiagnosis and Photodynamic Therapy Artigo DOI: 10.1016/j.pdpdt.2017.06.016

  3. Montanha, M. C.; Silva, L. L.; Pangoni, F. B. B.; Cesar, G. B.; Gonçalves, R. S.; Caetano, W.; Hioka, N.; Tominaga, T. T.; Consolaro, M. E. L.; Diniz, A.; Kimura, E.

    Response surface method optimization of a novel Hypericin formulation in P123 micelles for colorectal cancer and antimicrobial photodynamic therapy

    Journal of Photochemistry and Photobiology B: Biology Artigo DOI: 10.1016/j.jphotobiol.2017.04.008

2016

  1. Tunin, L. M.; Borghi, F. B.; Nogueira, A. C.; Higachi, L.; Barbosa, D. S.; Baesso, M. L.; Hernandes, L.; Diniz, A.; Torrado Truiti, M. d. C.

    Employing photoacoustic spectroscopy in the evaluation of the skin permeation profile of emulsion containing antioxidant phenolic-rich extract ofMelochia arenosa

    Pharmaceutical Biology Artigo DOI: 10.3109/13880209.2015.1021817

  2. Lachi‐Silva, L.; Sousa, J. P. B.; Montanha, M. C.; Sy, S. K. B.; Lopes, J. L. C.; Silva, D. B.; Lopes, N. P.; Diniz, A.; Kimura, E.

    Rapid and efficient method for the quantification of lychnopholide in rat plasma by liquid chromatography–tandem mass spectrometry for pharmacokinetic application

    Biomedical Chromatography Artigo DOI: 10.1002/bmc.3654

  3. Borghi-Pangoni, F. B.; Junqueira, M. V.; de Souza Ferreira, S. B.; Silva, L. L.; Rabello, B. R.; Caetano, W.; Diniz, A.; Bruschi, M. L.

    Screening and In Vitro Evaluation of Mucoadhesive Thermoresponsive System Containing Methylene Blue for Local Photodynamic Therapy of Colorectal Cancer

    Pharmaceutical Research Artigo DOI: 10.1007/s11095-015-1826-8

2015

  1. Buqui, G. A.; Sy, S. K.; Merino-Sanjuán, M.; Gouvea, D. R.; Nixdorf, S. L.; Kimura, E.; Derendorf, H.; Lopes, N. P.; Diniz, A.

    Characterization of intestinal absorption of C -glycoside flavonoid vicenin-2 from Lychnophora ericoides leafs in rats by nonlinear mixed effects modeling

    Revista Brasileira de Farmacognosia Artigo DOI: 10.1016/j.bjp.2015.04.001

  2. Guedes, B. L. d. S.; Montanha, M. C.; Teixeira, J. J. V.; Diniz, A.; Silva, S. R. B.; Previdelli, I.; Nasser, D.; Yamada, S. S.; Kimura, E.

    Clinicians' prescribing practices for bariatric surgery patients: is there an issue?

    Journal of Clinical Pharmacy and Therapeutics Artigo DOI: 10.1111/jcpt.12217

  3. Borghi-Pangoni, F. B.; Tunin, L. M.; Bonifácio, K. L.; Nogueira, A. C.; Hernandes, L.; Yamashita, F.; Barbosa, D. S.; Baesso, M. L.; Truiti, M. d. C. T.; Diniz, A.

    Nectandra falcifolia: potential phytopharmaceutical for skin damage protection designed by statistical approach and characterized by photoacoustic spectroscopy

    Revista Brasileira de Farmacognosia Artigo DOI: 10.1016/j.bjp.2015.02.012

  4. Buqui, G.; Gouvea, D.; Sy, S.; Voelkner, A.; Singh, R.; da Silva, D.; Kimura, E.; Derendorf, H.; Lopes, N.; Diniz, A.

    Pharmacokinetic Evaluation of Avicularin Using a Model-Based Development Approach

    Planta Medica Artigo DOI: 10.1055/s-0035-1545728

  5. Lachi-Silva, L.; Sy, S.; Voelkner, A.; de Sousa, J.; Lopes, J.; Silva, D.; Lopes, N.; Kimura, E.; Derendorf, H.; Diniz, A.

    Simultaneous Characterization of Intravenous and Oral Pharmacokinetics of Lychnopholide in Rats by Transit Compartment Model

    Planta Medica Artigo DOI: 10.1055/s-0035-1546214

  6. dos Santos, A. H.; Ramos, A. C.; Silveira, K. M.; Kiss, A. C. I.; Longhini, R.; Diniz, A.; de Mello, J. C. P.; Gerardin, D. C. C.

    The exposure to Trichilia catigua (catuaba) crude extract impairs fertility of adult female rats but does not cause reproductive damage to male offspring

    Journal of Ethnopharmacology Artigo DOI: 10.1016/j.jep.2015.03.018

2014

  1. Shadowing and pruning on the development and polyphenol contents in Maytenus ilicifolia,Desenvolvimento de maytenus ilicifolia e de seus polifenóis totais sob condição de sombreamento e poda

    Revista Brasileira de Plantas Medicinais Artigo

2013

  1. Rigobello, C.; Gasparetto, A. V.; Diniz, A.; Rabito, M. F.; Nery, M. M. F.

    Avaliação da qualidade e perfil de dissolução de comprimidos de cloridrato de propranolol

    Acta Scientiarum. Health Science Artigo DOI: 10.4025/actascihealthsci.v35i1.12307

2012

  1. Serpa, R.; França, E. J. G.; Furlaneto-Maia, L.; Andrade, C. G. T. J.; Diniz, A.; Furlaneto, M. C.

    In vitro antifungal activity of the flavonoid baicalein against Candida species

    Journal of Medical Microbiology Artigo DOI: 10.1099/jmm.0.047852-0

2011

  1. de Araujo, B. V.; Diniz, A.; Palma, E. C.; Buffé, C.; Costa, T. D.

    PK-PD modeling of β-lactam antibiotics: In vitro or in vivo models?

    The Journal of Antibiotics Artigo DOI: 10.1038/ja.2011.29

  2. Fernandes, C. R.; Turatti, A.; Gouvea, D. R.; Gobbo-Neto, L.; Diniz, A.; Ribeiro-Silva, A.; Lopes, N. P.; Garcia, S. B.

    The Protective Role of Lychnophora ericoides Mart. (Brazilian Arnica) in 1,2-Dimethylhydrazine-Induced Experimental Colon Carcinogenesis

    Nutrition and Cancer Artigo DOI: 10.1080/01635581.2011.539310

2010

  1. Jabor, V. A. P.; Soares, D. M.; Diniz, A.; de Souza, G. E. P.; Lopes, N. P.

    LC-MS-MS Identification and Determination of the Flavone- C -Glucoside Vicenin-2 in Rat Plasma Samples Following Intraperitoneal Administration of Lychnophora Extract

    Natural Product Communications Artigo DOI: 10.1177/1934578x1000500513

2008

  1. Diniz, A.; Escuder-Gilabert, L.; Lopes, N. P.; Villanueva-Camañas, R. M.; Sagrado, S.; Medina-Hernández, M. J.

    Characterization of interactions between polyphenolic compounds and human serum proteins by capillary electrophoresis

    Analytical and Bioanalytical Chemistry Artigo DOI: 10.1007/s00216-008-2046-4

  2. Costa, R. d. J.; Diniz, A.; Mantovani, M. S.; Jordão, B. Q.

    In vitro study of mutagenic potential of Bidens pilosa Linné and Mikania glomerata Sprengel using the comet and micronucleus assays

    Journal of Ethnopharmacology Artigo DOI: 10.1016/j.jep.2008.03.014

2007

  1. Diniz, A.; Escuder-Gilabert, L.; Lopes, N. P.; Gobbo-Neto, L.; Villanueva-Camañas, R. M.; Sagrado, S.; Medina-Hernández, M. J.

    Permeability Profile Estimation of Flavonoids and other Phenolic Compounds by Biopartitioning Micellar Capillary Chromatography

    Journal of Agricultural and Food Chemistry Artigo DOI: 10.1021/jf070730r