Physicochemical properties determine whether a drug dissolves, crosses membranes and reaches its target. PKBio measures these properties under conditions that mimic the body, generating data that directly feed the pharmacometric models.
What we do
- Thermodynamic and apparent solubility, including media that simulate gastrointestinal conditions.
- pKa (ionization constant), which defines the predominant form of the molecule at each pH.
- Plasma protein binding, which determines the unbound fraction — the one that acts and is eliminated.
Why it matters
These parameters guide formulation choices, explain differences in absorption and reduce the uncertainty of PBPK and PBBM models.