Animal studies show how absorption and elimination happen in a living organism. In this line, PKBio designs and analyzes preclinical pharmacokinetic studies, with attention to the minimum number of animals and to sampling quality.
What we do
- Study design with sampling schedules that describe the absorption and elimination phases well.
- Quantification of samples with the bioanalytical methods validated in the laboratory.
- Analysis of plasma concentration–time profiles with non-compartmental, compartmental and physiologically based approaches.
Why it matters
Good-quality in vivo data validate in silico models and allow results to be extrapolated more safely to other species and to the clinic.