Pharmacometrics and modeling
PBPK, PopPK and PBBM models and in silico prediction to anticipate drug exposure and support dosing decisions.
Research lines
Research
Our research connects experimental data and mathematical models to answer questions about drug absorption, distribution and elimination.
Analytical and bioanalytical methods
Development and validation of HPLC-UV, DAD, MS and MS/MS methods to quantify drugs in formulations and biological matrices.
Physicochemical and biopharmaceutical characterization
Thermodynamic and apparent solubility, pKa and plasma protein binding — properties that govern absorption and distribution.
Preclinical pharmacokinetics
Absorption kinetic profiles in animal models, with sampling designed to feed models and dosing decisions.