PKBio · UEM

Laboratory of Pharmacokinetics and Biopharmaceutics

Pharmacokinetic modeling, bioanalytical methods and biopharmaceutical characterization to understand — and predict — how drugs behave in the body.

Research

Research lines

From the bench experiment to the in silico model: four complementary fronts.

PBPK, PopPK and PBBM models and in silico prediction to anticipate drug exposure and support dosing decisions.

Development and validation of HPLC-UV, DAD, MS and MS/MS methods to quantify drugs in formulations and biological matrices.

Thermodynamic and apparent solubility, pKa and plasma protein binding — properties that govern absorption and distribution.

Absorption kinetic profiles in animal models, with sampling designed to feed models and dosing decisions.

Publications

de Goes, P. R. N.; Taffarel, M. O.; Diniz, A.

Application of physiologically‐based pharmacokinetic modelling to guide oral ketamine prescription in analgesic doses

British Journal of Clinical Pharmacology 2026 Article DOI: 10.1002/bcp.70662
Piai, J. M. B.; Lippa, V. N. M.; Caleffi-Marchesini, E. R.; Borghi Pangoni, F. B.; Felipe, M. S.; Kioshima, E. S.; Diniz, A.

Integrating Experimental Physicochemical Data with PBPK Modeling to Guide the Translational Development of the Antifungal 1,3,4-Oxadiazole Derivative LMM6

ACS Omega 2026 Article DOI: 10.1021/acsomega.6c00258
Alencar, C. R. K. d.; Lachi-Silva, L.; Goes, P. R. N. d.; Sakamoto, G. F.; Diniz, A.; Ferrante, M.; Oliveira, A. R. d.; Trindade, P. H. E.; Puoli Filho, J. N. P.; Luna, S. P. L.; Taffarel, M. O.

Pharmacokinetics of oral-transmucosal ketamine in horses

Ciência Rural 2026 Article DOI: 10.1590/0103-8478cr20240251

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